When choosing artwork for your home, it is important to choose pieces that generate some kind of emotion. Hedy Lamarr once said, "A good painting to me has always been like a friend. It keeps me company, comforts and inspires." Also like a friendship, artwork is a personal choice. What someone could consider comforting may be the complete opposite to someone else.
The easiest way to figure out what type of artwork you gravitate toward most, visit your local art museum and notice what exhibits you stare at longest. Also, make sure you match the artwork to the type of mood you are going for in a room. For example, if you are going for "relaxed and calming" in a sitting room, close your eyes and try to picture what relaxed and calming looks like to you. Is it a bird sitting on a telephone line? Is it a deserted beach with a breeze? Or is it just blocks of blues and grays? Whatever it is, use this as the starting point when choosing your artwork.
If you've got the cash, visit a gallery and invest in something you love. If you're more of a bargain shopper, check out Art.com or Etsy. Other interesting places for artwork are Powerhouse Factories, GigPosters.com and ThePosterList.com. Here are some on my wish list.